Imaging Instruments EEG – Electroencephalogram## Imaging Instruments EEG – Electroencephalogram

EEG is a test to evaluate the electrical activities of the brain (Figure12.5). Brain cells communicate with each other through electrical impulses. An EEG

tracks and records the brain wave patterns. It is a graphical recording of the electrical activities of the cortical and sub cortical regions of the brain. It is recorded by placing the surface electrodes on the scalp region. The electrodes analyse the electrical impulses in the brain and send signals to a computer which records the results. In 1929 Germen scientist Hans Berger was the first to analyse the EEG. Hence, EEG is also known as “Berger Wave”. The electrical activity recorded by EEG may have synchronised or desynchronised waves. It has four frequency waves/ rhythms namely alpha, beta, delta and theta waves**.**

Clinical significance of EEG

1. EEG provides a means to study the functioning of the brain and its coordination with other parts of the body.

2. It is useful in diagnosis of neurological and sleep disorders

X-rays

Radiography is the use of X-rays to visualize the internal structures of a patient (Figure12.6). X-Rays are a form of

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3. EEG has proved to be a useful diagnostic tool in cases of serious head injuries, brain tumours and cerebral infections.

4. It also helps to find the diseases like epilepsy and various degenerative disease of the nervous system.

5. EEG is useful in assessing patients with suspected brain death.

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electromagnetic radiation, produced by an X-ray tube. The X-rays are passed through the body and captured behind the patient by a detector; film sensitive to x-rays or a digital detector. There is variation in absorption of the X-rays by different tissues within the body. Dense bones absorb more radiation, while soft tissue allows more rays to pass through. This variation produces contrast image within the image to give a 2D representation of all the structures. It is invasive. It is also available as a portable X ray unit. It is less costly when compared to the other imaging units like MRI or CT.

Clinical significance 1. X- ray imaging is used for diagnosing

the disease of the heart, lungs and fractures of bones and joints

2. It is also used to visualise hollow organs and blood vessels by filling them with certain chemical formulations containing barium and iodine

3. Dental radiography is used in diagnosis of oral problems

4. Mammography is a special type of X-ray imaging to create detail images of the breast tissues

5. Fluoroscopy for real time images 6. X-rays are used in radiation therapy to

shrink cancerous tumours

igure 12.5 EEG with waves

‘X rays were discovered by German physicist Sir Wilhelm Conard Roentgen in 1895,

while he was studying on high voltage discharge phenomenon in a Crooker’s tube. He noticed fluorescence of a barium platino cyanide screen lying several feet away in the same room.

Ultrasound imaging

Ultrasound literally means sound beyond the range of human hearing. Ultrasound waves are produced by a physical phenomenon known as Piezo-electric effect. When an electric potential is applied to certain crystals for example: Lead zirconate, they become excited, vibrate and produce ultrasound. When the ultrasound waves are introduced through homogenous tissue, they pass unimpeded until they

meet another tissue or organ. A part or whole of the ultrasound wave is reflected and received back by the same crystal and is converted into an electrical signal. This signal denoting reflecting interface is shown on the oscilloscope screen as a deflection from the base line (Figure12.7).

Clinical significance

1. Ultrasound waves are used to image the foetus at different stages of pregnancy to study the progress of the developing foetus.

2. They are used to hear foetal heart sound, blood flow, etc.

3. Used in echocardiography to diagnose the damages in heart.

4. Used for diagnosis of tumours, gall stones, kidney stones, obstructions in the genital tracts.

Computed Tomographic (CT) Scanning

Computed tomography is originally known as computed axial tomography (CAT or CT Scan). The word tomography

is derived from the Greek word tomos means slice and graphe means to write. It is a medical imaging technology employing tomography, were digital geometry processing is used to generate a three dimensional image of the internals of an object from a large series of two dimensional X ray images taken around a single axis of rotation (Figure12.8).

CT produces volumes of data which can be manipulated through a process known as windowing in order to demonstrate various structures based on their ability to block the X ray beam.

Clinical significance • Gives a clear image of bone, soft tissues

and blood vessels • Helps in the diagnosis of injuries of

the inner ears and sinuses • To detect cancer, heart and lung

disorders • For diagnosis of spinal problems and

skeletal injuries • Helps to measure bone mineral density • To detect stroke causing clots and

hemorrhage in the brain.

Positron Emission Tomographic Scanning (PET)

PET is also computerized imaging technique unlike CT. Positron emission

tomography (PET) is a nuclear medicine procedure based on the measurement of positron emission from radiolabelled tracer molecules. These radiotracers allow biological processes to be measured and whole body images to be obtained which demonstrates sites of radiotracer accumulation. A PET image gives quantitative regional information on the metabolic and physiological processes. PET uses positron emitting radio isotopes (11C 13N 15O 18F) which are generated by the cyclotron. The most common radiotracer in use today is 18F-fluorodeoxyglucose (18F-FDG) which is a radio labelled sugar (glucose) molecule. These atoms are then incorporated by chemical methods into biological molecules like glucose, amino acids and ammonia. These positron emitting compounds are then injected in very small amounts into or inhaled by experimental animals or human subjects. The three dimensional distribution of the labeled trace is then probed by powerful PET cameras and the images are reconstructed by a computer. The quantitative interpretation of the image is done by varying mathematical models. They deal with the process of uptake and metabolism of the radioisotope.

Clinical significance

PET imaging is effectively used in the measurement of regional cerebral blood volume, blood flow, metabolic rates for glucose and oxygen in humans.

MRI-Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a non-invasive medical test that physicians use to diagnose medical conditions.

Unlike conventional X-ray examinations and computed tomography (CT) scans, MRI does not utilize ionizing radiation. MRI uses a powerful magnetic field, radio frequency pulses and a computer to produce detailed pictures of organs, soft tissues, bone and virtually all other internal body structures. The radio frequency pulses re-align hydrogen atoms that naturally exist within the body while the patient is in the scanner without causing any chemical changes in the tissues. As the hydrogen atoms return to their usual alignment, they emit different amounts of energy that vary according to the type of body tissue from which they come. The MR scanner captures this energy and creates a picture of the tissues scanned based on this information (Figure12.9).

The magnetic field is produced by passing an electric current through wire coils in most MRI units. Other coils, located in the machine and in some cases, are placed around the part of the body being imaged, send and receive radio waves, producing signals that are detected by the coils. The electric current does not come in contact with the patient.

A computer then processes the signals and generates a series of images, each of which shows a thin slice of the body. The images can then be studied from different angles and interpreted by a radiologist.

Frequently, the differentiation of abnormal (diseased) tissue from normal tissues is better with MRI than with other imaging modalities such as X-ray, CT and ultrasound. Detailed MR images allow physicians to evaluate various parts of the body and determine the presence of certain diseases. The images can then be examined on a computer monitor,

transmitted electronically, printed or copied to a CD or uploaded to a digital cloud server.

Figure 12.9 Artificially coloured MRI scan of human brain

Clinical significance

MR imaging of the body is performed to evaluate organs of the chest and abdomen, pelvic organs including the bladder and the reproductive organs, blood vessels and lymph nodes.

Physicians use an MR examination to help diagnose or monitor treatment for conditions such as:

• Tumours of the chest, abdomen or pelvis.

• Diseases of the liver, inflammatory bowel disease, heart problems, such as congenital heart disease.

• Malformation of the blood vessels and inflammation of the vessels (vasculitis).

• A foetus in the womb of a pregnant woman. • Visualising injuries, torn ligaments

especially in areas like wrist ankle or knee.

Why the magnetic resonance imaging technique gives excellent job of showing soft tissues and blood vessels?